Urinary tract infections are the second most common infections seen in physicians offices. These infections are common in sexually active women, diabetics, elderly men with prostate gland obstruction and persons with kidney stones. The conventional therapy with antibiotics may create bacteria that are resistant to antibiotics particularly when there is obstruction to the drainage of urine by enlarged prostate glands or stones.

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Mannitol is a sugar that has the interesting property of being able to dislodge bacteria from the membranes lining the bladder, ureter and pelvis of the kidney. Most bacteria become unable to retain their attachments to the bladder lining when exposed to mannitol. This results in clearing of approximately 80 % of urinary tract infections. The improvement occurs without danger of the urinary bacteria becoming resistant to the mannitol as occurs with antibiotic therapy. Mannitol has no adverse effects on blood sugar.
Mannitol is a safe effective therapy for most urinary tract infections.

The usual dose of mannitol is ½ teaspoon every three hours. When symptoms are alleviated the dose can be decreased to four times daily for a week. Severe kidney infections [pyelonephritis](pain in flanks with fever) should be treated with mannitol ½ teaspoon every 2 hours until improvement is seen when the dosage can be decreased to four times daily. A maintenance dose of ½ teaspoon twice daily for three to four weeks is often advisable for severe infections.

Most bladder and kidney infections can be eliminated without side effects by mannitol therapy.

Therapy of urinary tract infections can be instituted with the sugar mannitol which is quite safe. Mannitol therapy avoids drug side effects and does not lead to resistant bacteria as it has no influence on the metabolism of bacteria.
Women who have frequent episodes of cystitis after intercourse may obtain relief from this problem by taking mannitol ½ teaspoon one half hour before and an hour after intercourse.
Mannitol permits patients with urinary infections to avoid the damage to the healthy intestinal bacteria caused by antibiotic drugs. This loss of healthy bacteria injures the immune system if these health bacteria are not replaced and can thus lead to problems with infections and the risk of breast malignancy1 becomes increased.
1. Increased incidence of breast cancer in women who have taken antibiotic therapy. Journal of American Medical Association Feb 18, 2004